A case of presumed herpes keratouveitis in a patient treated with fingolimod
نویسندگان
چکیده
We discuss a case of presumed bilateral herpes simplex keratouveitis in a 36-year-old multiple sclerosis patient switched to fingolimod from glatiramer acetate. Fingolimod treatment appears to increase the risk of herpesvirus infections, including with herpes simplex virus and varicella zoster virus. This case report reviews the potential immunology behind this risk, and identifies the need for further research, including ways to minimize and stratify risk for herpesvirus reactivation.
منابع مشابه
[Bilateral herpetic keratouveitis in an immunocompetent patient].
CASE REPORT We report the case of an immunocompetent male who presented with a limbal-adjacent scleritis and interstitial keratitis in the left eye. A few days later a new dendritiform ulcer in his right eye and bilateral progressive worsening with granulomatous uveitis in both eyes were observed. A thorough review of systems revealed positive serum IgM titles for herpes simplex virus. DISCUS...
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Fingolimod is an oral, disease-modifying therapy used to treat multiple sclerosis (MS). However, severe viral infections, including disseminated varicella-zoster virus infection, herpes simplex encephalitis, varicella-zoster virus encephalitis and vasculopathy, or progressive multifocal leukoencephalopathy, have been reported during fingolimod therapy. Hemophagocytic lymphohistiocytosis (HLH), ...
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Fingolimod is a new oral administrated sphingosine 1phosphate receptor modulator, approved for treatment of multiple sclerosis (MS) patients.1,2 There is evidence that fingolimod acts by preventing lymphocyte egress from lymph nodes, spleen and thymus by antagonistic action on the sphingosine 1-phosphate receptors. These receptors regulate proliferation, differentiation, survival, chemotaxis an...
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OBJECTIVE To report recurrent herpetic keratouveitis following YAG laser peripheral iridotomy. METHODS Case report. RESULTS A 64-year-old woman with a history of dendritic keratitis underwent Nd:YAG laser peripheral iridotomy and developed geographic epithelial keratitis with stromal keratouveitis. Culture of a corneal swab grew herpes simplex virus type I. Keratouveitis subsided with acycl...
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